CONCLUSION By adjusting viscosity grade of EC and concentration of EC solution, capsule bodies may be impermeable within a certain period of time obtained using filling method, which provider foundation for further preparation of pulsatile drug delivery device for chronotherapy. 结论调整EC黏度级别和EC浓度,用灌注法可制备在一定时间内保持非渗透的合适胶囊体,为进一步制备用于时辰治疗的脉冲释药装置奠定基础。